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Frontiers | A Review of the Therapeutic Potential of Recently Developed G  Protein-Biased Kappa Agonists
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists

Opioid Receptors Mnemonic | Epomedicine
Opioid Receptors Mnemonic | Epomedicine

Pharmaceuticals | Free Full-Text | Therapeutic Potential of Kappa Opioid  Agonists
Pharmaceuticals | Free Full-Text | Therapeutic Potential of Kappa Opioid Agonists

Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands:  Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience
Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience

Nanobody-enabled monitoring of kappa opioid receptor states | Nature  Communications
Nanobody-enabled monitoring of kappa opioid receptor states | Nature Communications

Frontiers | The Kappa Opioid Receptor: From Addiction to Depression, and  Back
Frontiers | The Kappa Opioid Receptor: From Addiction to Depression, and Back

Mu Opiate Receptor Agonist - an overview | ScienceDirect Topics
Mu Opiate Receptor Agonist - an overview | ScienceDirect Topics

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes  for the Kappa Opioid Receptor | Journal of Medicinal Chemistry
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor | Journal of Medicinal Chemistry

A unique natural selective kappa-opioid receptor agonist, salvinorin A, and  its roles in human therapeutics - ScienceDirect
A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics - ScienceDirect

Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding  by Rhesus Monkeys | Journal of Pharmacology and Experimental Therapeutics
Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding by Rhesus Monkeys | Journal of Pharmacology and Experimental Therapeutics

Cara Therapeutics: Scratching An Itch Left Unscratched (NASDAQ:CARA) |  Seeking Alpha
Cara Therapeutics: Scratching An Itch Left Unscratched (NASDAQ:CARA) | Seeking Alpha

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist  Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical  Neuroscience
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical Neuroscience

Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse |  National Institute on Drug Abuse (NIDA)
Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)

Structure–activity relationship investigation of triazole-based kappa  opioid receptor agonists | SpringerLink
Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists | SpringerLink

Nalfurafine, a G-Protein–Biased KOR (Kappa Opioid Receptor) Agonist,  Enhances the Diuretic Response and Limits Electrolyte Losses to  Standard-of-Care Diuretics | Hypertension
Nalfurafine, a G-Protein–Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics | Hypertension

Will peripherally restricted kappa‐opioid receptor agonists (pKORAs)  relieve pain with less opioid adverse effects and abuse potential? -  Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics -  Wiley Online Library
Will peripherally restricted kappa‐opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential? - Albert‐Vartanian - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

Mu Agonist Opioids and Kappa Opioids | Download Table
Mu Agonist Opioids and Kappa Opioids | Download Table

Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel  Kappa Opioid Receptor Agonist Scaffold | ACS Chemical Neuroscience
Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold | ACS Chemical Neuroscience

Opioid Receptor | kappa, mu Opioid Receptor
Opioid Receptor | kappa, mu Opioid Receptor

BRL 52537 hydrochloride, kappa-opioid agonist (CAS 112282-24-3) (ab120669)
BRL 52537 hydrochloride, kappa-opioid agonist (CAS 112282-24-3) (ab120669)

Frontiers | A Review of the Therapeutic Potential of Recently Developed G  Protein-Biased Kappa Agonists
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists

Mixed Kappa/Mu Partial Opioid Agonists as Potential Treatments for Cocaine  Dependence - ScienceDirect
Mixed Kappa/Mu Partial Opioid Agonists as Potential Treatments for Cocaine Dependence - ScienceDirect

Opioids: classification, uses, action and dependence - MedicalVerge
Opioids: classification, uses, action and dependence - MedicalVerge

EX-99.2
EX-99.2

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist  Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical  Neuroscience
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical Neuroscience

Biased agonists of the kappa opioid receptor suppress pain and itch without  causing sedation or dysphoria | Science Signaling
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling

Kappa Receptors – Opioid Peptides
Kappa Receptors – Opioid Peptides

Table II from Systemic kappa opioid receptor agonists in the treatment of  chronic pruritus: a literature review. | Semantic Scholar
Table II from Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review. | Semantic Scholar